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One centers on Snowball's plan to take over the world using Microsponge (a parody of Microsoft). The bulk of every episode involves one of Brain's plans for world domination with Pinky's assistance and the ultimate failure of that plan, with some exceptions.

There is very little continuity between episodes outside of the common fixtures of the two mice, though some plans for world domination from early episodes are subsequently referred to in later seasons for example, Brain's mechanical human suit that was first used in 'Win Big' reappears when Brain faces his rival Snowball in 'Snowball'. Wells, Ivan Pavlov, and Johannes Gutenberg.

Several episodes take place in historical times, with Pinky and Brain in the laboratory of some scientifically-minded person, including Merlin, H.G. Many of the Pinky and the Brain episodes occur in the 1990s at Acme Labs, located in some large American city underneath a suspension bridge. In common with many other Animaniacs shorts, many episodes are in some way a parody of something else, usually a film or novel. In each episode, Brain devises a new plan to take over the world which ultimately ends in failure, usually due to the impossibility of Brain's plan, Brain's own overconfidence, Pinky's bumbling, an oversight on Brain's part, circumstances beyond their control, or multiples thereof.

Brain is highly intelligent, self-centered and scheming, while Pinky is good-natured but feeble-minded. Pinky and the Brain are genetically enhanced laboratory mice who reside in a cage in the Acme Labs research facility. The characters later appeared in the series Pinky, Elmyra & the Brain, and have since returned to their roots as an Animaniacs segment in the 2020 revival of that series. It was later spun off as a series due to its popularity, with 65 episodes produced. The characters first appeared in 1993 as a recurring segment on the animated television series Animaniacs. It was the first animated television series to be presented in Dolby Surround and a collaboration of Steven Spielberg with his production company Amblin Television and Warner Bros. Pinky and the Brain is an American animated television series created by Tom Ruegger for the Kids' WB programming block of The WB.

Download pinky and the brain and animaniacs